Table 1.

LCV lytic infection proteins selected for study

rhLCV protein% aa similarity to EBV homologueaFunctionPresence of serum antibody response in humansb
BZLF171TransactivatorYes
BRLF176TransactivatorRare
BALF290DNA binding proteinYes
BARF175CSF1-R homologueNPC
BMRF186DNA processivity factorYes
BMLF180mRNA export factorUnknown
BALF595DNA polymeraseRare
BHRF173Bcl2 homologueRare
BALF486Glycoprotein BYes
BILF275gp78Yes
BLLF149gp350Yes
BDLF347gp150Yes
BBRF193Capsid protein (portal protein)Unknown
BVRF266Capsid protein (protease)Unknown
  • a aa, amino acid.

  • b “Yes” indicates that serum antibody responses to that protein are widespread and robust in humans. “Rare” indicates that serum antibody responses to that protein are frequent but less robust in humans. “Unknown” indicates that serum antibody responses in humans have not been described for that protein. “NPC” indicates that serum antibody responses are present primarily in NPC patients.