Table 1.

Comparison of the time course of antigenuria and antigenemia during amphotericin B therapy

ParameterSpecimenValue at:
2 wk4 wk8 wk12 wk
Significant decline (%)aUrine55.863.284.985.7
Serum56.869.275.877.8
P value1.000.4910.3170.317
Decline to <4 ng/ml (%)Urine7.015.824.225.7
Serum31.859.075.883.3
P value0.0009<0.0001<0.0001<0.0001
Decline to <10 ng/ml (%)Urine30.239.542.251.4
Serum65.982.197.091.7
P value0.00010.0002<0.00010.0002
Mean decline (ng/ml)Urine7.659.7314.2914.64
Serum11.2615.6017.1618.52
P value0.09480.00930.15430.0440
Median decline (ng/ml)Urine6.667.5414.5512.49
Serum3.518.557.9311.37
  • a Significant reduction in antigen level is defined as a reduction greater than 15% when baseline values are ≥20 ng/ml or a reduction greater than 3 ng/ml when baseline values are <20 ng/ml.