Table 2.

Comparison of the time course of antigenuria between amphotericin B (AmB) and itraconazole (Itra) therapy

ParameterTreatmentValue at:
2 wk4 wk8 wk12 wk
Significant decline (%)aAmB55.863.284.985.7
Itra13.928.129.062.2
P value0.00010.0034<0.00010.023
Decline to <4 ng/ml (%)AmB7.015.824.225.7
Itra5.69.46.527.0
P value0.7960.4240.0500.899
Decline to <10 ng/ml (%)AmB30.239.542.251.4
Itra25.034.441.951.4
P value0.6050.6600.9680.995
Mean decline (ng/ml)AmB7.659.7314.2914.64
Itra0.060.300.907.86
P value0.00020.0002<0.00010.0114
Median decline (ng/ml)AmB6.667.5414.5512.49
Itra0.00.00.254.69
  • a Significant reduction in antigen level is defined as a reduction greater than 15% when baseline values are ≥20 ng/ml or a reduction greater than 3 ng/ml when baseline values are <20 ng/ml.