TABLE 3.

Antibody responses by prespecified age groupings at day 14 postvaccination

Age group (yr) and parameterValue for group (95% CI)
V710 5 μg (n = 31)V710 30 μg (n = 28)V710 90 μg (n = 31)Placebo (n = 28)
18-39
    % of subjects with ≥2-fold rise in antibody concn (positive response)29 (10, 56)85 (55, 98)78 (52, 94)8 (0, 36)
    Geometric mean antibody concn (μg/ml)47 (33, 67)113 (74, 172)116 (79, 169)37 (24, 57)
    Geometric mean fold rise in antibody concn from baseline1.7 (1.4, 2.0)3.4 (2.5, 4.6)4.8 (3.0, 7.9)1.1 (0.8, 1.6)
40-55
    % of subjects with ≥2-fold rise in antibody concn (positive response)29 (8, 58)87 (60, 98)100 (75, 100)0 (0, 22)
    Geometric mean antibody concn (μg/ml)55 (35, 88)119 (84, 168)156 (110, 223)15 (9, 27)
    Geometric mean fold rise in antibody concn from baseline2.0 (1.2, 3.1)5.4 (3.5, 8.5)6.6 (4.4, 9.7)0.9 (0.8, 1.0)