TABLE 2.

Quantitative correlates and surrogates of protection after vaccination

VaccineTestLevel requiredReference(s)a
AnthraxToxin neutralization1,000 IU/ml 87, 136, 149, 170, 191
DiphtheriaToxin neutralization0.01-0.1 IU/ml 14, 92
Hepatitis AELISA10 mIU/ml 45, 110
Hepatitis BELISA10 mIU/ml 66
Hib polysaccharidesELISA1 μg/ml 74
Hib conjugateELISA0.15 μg/ml 73
Human papillomavirusELISANDb 140
InfluenzaHAI1/40 dilution 50, 171
Japanese encephalitisNeutralization1/10 dilution 63
Lyme diseaseELISA1,100 EIA U/ml 128
MeaslesMicroneutralization120 mIU/ml 24, 120, 158
MeningococcalBactericidal1/4 (human complement) 96
MumpsNeutralization?ND 189
PertussisELISA (toxin)5 units 25, 173, 180.
PneumococcusELISA; opsonophagocytosis0.20-0.35 μg/ml (for children); 1/8 dilution 68, 81, 167
PolioNeutralization1/4-1/8 dilution 41, 95, 139
RabiesNeutralization0.5 IU/ml 196,
RotavirusSerum IgAND 49, 67, 104, 199, 200
RubellaImmunoprecipitation10-15 mIU/ml 2, 27, 53, 99, 141, 169
TetanusToxin neutralization0.1 IU/ml 13, 37,
SmallpoxNeutralization1/20 89, 93, 139, 160
Tick-borne encephalitisELISA125 IU/ml 77
TuberculosisInterferonND 46
VaricellaFAMA gp ELISA≥1/64 dilution; ≥5 IU/ml 195
Yellow feverNeutralization1/5 79, 97
ZosterCD4+ cell; lymphoproliferationND 190
  • a Also see the text.

  • b ND, not defined.