TABLE 2.

Characteristics and cytokine expression of TB patients stratified by treatment outcome at 2 monthsa

CharacteristicLate responders (n = 12)Early responders (n = 20)P
Age (yr)b63.5 (43.8, 79.5)50 (39.3, 74.3)0.255
Genderd0.581
    Male10 (83.3)18 (90.0)
    Female2 (16.7)2 (10.0)
Smokingd0.381
    Never8 (66.7)16 (80.0)
    Previous1 (8.3)0 (0.0)
    Current3 (25.0)4 (20.0)
Severity of lung diseasec0.854
    Limited5 (41.7)9 (45.0)
    Extended7 (58.3)11 (55.0)
Predominant lung patternc0.149
    Coalescent6 (50.0)15 (75.0)
    Disseminated6 (50.0)5 (25.0)
AFB smear result before therapyc0.102
    Negative10 (83.3)11 (55.0)
    Positive2 (16.7)9 (45.0)
AFB smear result after 2 mo0.114
    Negative7 (58.3)14 (70.0)
    Positive5 (41.7)6 (30.0)
Sputum TB culture result after 2 mo<0.001*
    Negative0 (0.0)14 (70.0)
    Positive12 (100.0)6 (30.0)
Cytokine concn (pg/ml) before anti-TB therapy
    TNF-αb36.5 (33.1, 40)34.5 (32.7, 37.8)0.239
    IL-6b10.6 (9.2, 12.5)9.4 (9.3, 10.5)0.659
    IL-8b901.2 (762.8, 3,457.9)892.1 (827, 2,267.4)0.833
    IL-10b29.3 (28.2, 32.4)30.5 (29.8, 32.1)0.346
    IL-12b192.8 (189.3, 198.5)192.9 (188.9, 198.4)0.833
    MCP-1b4,470.1 (3,102.9, 6,371.6)3,206.6 (2,947.1, 5,134.3)0.136
    IFN-γb28.7 (27.2, 34.5)28 (27.4, 30)0.803
    IL-1βb31.5 (29.8, 59.7)30.7 (30.1, 35)0.578
    IP-10b236.8 (167.6, 333.5)189.1 (175.5, 226.1)0.387
Cytokine concn (pg/ml) 2 mo after anti-TB therapy
    TNF-αb41.3 (36.4, 52.5)30.2 (29.3, 32.6)<0.001*
    IL-6b10.3 (9.3, 12.3)9.4 (9.3, 10)0.272
    IL-8b925.4 (764.6, 1,617.7)737.8 (721.7, 783.2)0.005*
    IL-10b30.4 (28.8, 33)35.7 (32.2, 38.4)0.004*
    IL-12b193.5 (186.9, 201.2)179.5 (179.1, 184.8)<0.001*
    MCP-1b4,273.6 (2,979.5, 5,621.1)2,922.3 (2,809.7, 3,024.4)0.001*
    IFN-γb28.6 (27.2, 33.1)25.7 (25.4, 26.2)<0.001*
    IL-1βb30.9 (30, 65.8)29.6 (28.9, 29.9)<0.001*
    IP-10b226.0 (167.5, 344.6)169.8 (167.7, 180.5)0.064
Cytokine concn (pg/ml) 5 mo after anti-TB therapy
    TNF-αb33.1 (30.6, 34.4)30.6 (29.9, 32.1)0.032*
    IL-6b9.7 (9.2, 10)9.3 (9.3, 9.5)0.632
    IL-8b739.1 (726, 767.7)730.2 (718.6, 756)0.255
    IL-10b29.8 (28.3, 31.8)35.0 (32.8, 38.9)0.007*
    IL-12b189.6 (183.7, 194.7)181.2 (179.7, 184.6)<0.001*
    MCP-1b2,804.0 (2,775.6, 2,862.6)2,791.5 (2,780.6, 2,847.1)0.863
    IFN-γb27.4 (25.8, 29.4)25.8 (25.4, 26.5)0.004*
    IL-1βb30.1 (29, 30.5)29.3 (28.9, 29.9)0.070
    IP-10b176.5 (167.4, 188.9)170.0 (167.7, 174.6)0.209
  • a Data are for a total of 32 patients and are presented as medians (interquartile ranges) for continuous variables and numbers of individuals (percentages) for categorical variables. AFB, acid-fast bacillus; *, significant difference between the two groups (P < 0.05).

  • b P values were calculated by the Mann-Whitney U test for continuous variables.

  • c P values were calculated by the chi-square test for categorical variables.

  • d P values were calculated by Fisher's exact test for categorical variables.