TABLE 1.

Baseline characteristics of healthy participants and TB patientsa

CharacteristicControl subjects (n = 36)TB patients (n = 32)P
Age (yr)b40.0 (36.3, 70.3)52.5 (40.5, 75.8)0.117
Genderc0.866
    Male31 (86.1)28 (87.5)
    Female5 (13.9)4 (12.5)
Smokingd0.652
    Never25 (69.4)24 (75.0)
    Previous3 (8.3)1 (3.1)
    Current8 (22.2)7 (21.9)
Severity of lung disease
    Limited14 (43.8)NA
    Extended18 (56.3)
Lung pattern
    Coalescent21 (65.6)NA
    Infiltrative11 (34.4)
AFB smear result
    Negative21 (65.6)NA
    Positive11 (34.4)
Cytokine concn (pg/ml)
    TNF-αb28.9 (28.6, 40.3)34.7 (32.8, 38.9)0.001*
    IL-6b9.3 (9.2, 9.6)9.6 (9.2, 11.1)0.024*
    IL-8b750.4 (731.6, 763.4)901.2 (797.6, 2,267.4)<0.001*
    IL-10b30.2 (28.9, 35.7)30.4 (28.8, 32.4)0.610
    IL-12b183.2 (178.0, 199.4)192.9 (189.1, 198.5)0.005*
    MCP-1b2,793.2 (2,778.2, 2,853.5)3,717.2 (2,991.6, 5,277.3)<0.001*
    IFN-γb25.8 (24.8, 27.3)28.0 (27.4, 30.8)<0.001*
    IL-1βb28.9 (28.7, 30.5)30.8 (30.0, 43.0)<0.001*
    IP-10b171.5 (167.6, 181.7)197.0 (173.1, 251.4)<0.001*
  • a Data are for a total of 68 patients and are presented as medians (interquartile ranges) for continuous variables and numbers of individuals (percentages) for categorical variables. AFB, acid-fast bacillus; NA, not applicable; *, significant difference between the two groups (P < 0.05).

  • b P values were calculated by the Mann-Whitney U test for continuous variables.

  • c P values were calculated by the chi-square test for categorical variables.

  • d P values were calculated by Fisher's exact test for categorical variables.