TABLE 3.

Kinetics of cytokine expression for 32 TB patients stratified by treatment outcome at 2 monthsa

Cytokine concn (pg/ml) and time of measurementLate responders (n = 12)Early responders (n = 20)P for late responders
TNF-α0.076
    Before45.5 ± 24.840.2 ± 21.6
    After 2 mo57 ± 38.831 ± 2.7
    After 6 mo35.4 ± 7.931 ± 1.6
IL-60.442
    Before10.9 ± 1.712 ± 7.4
    After 2 mo11 ± 210.5 ± 3.1
    After 6 mo9.8 ± 0.89.6 ± 0.6
IL-80.914
    Before2,012.1 ± 2,124.52,323.8 ± 2,980.8
    After 2 mo1,574.4 ± 1,395.5834.9 ± 339.8
    After 6 mo747.2 ± 28.6736 ± 19.7
IL-100.821
    Before31.9 ± 6.133.2 ± 8.3
    After 2 mo31.4 ± 3.640 ± 15.7
    After 6 mo32 ± 5.639 ± 13.3
IL-120.136
    Before222.5 ± 99.7208.9 ± 62.5
    After 2 mo210.3 ± 59.8182.7 ± 7.2
    After 6 mo190.8 ± 8.5183.2 ± 7.4
MCP-10.041*
    Before7,042.5 ± 6,901.23,921.6 ± 1,247.5
    After 2 mo5,431.9 ± 3,628.82,977.9 ± 239.9
    After 6 mo2,827.6 ± 69.42,822.4 ± 67
IFN-γ0.061
    Before37 ± 23.130.5 ± 6.3
    After 2 mo33.9 ± 14.425.9 ± 0.9
    After 6 mo27.7 ± 1.926.0 ± 0.8
IL-1β0.247
    Before96.5 ± 198.335.6 ± 10.6
    After 2 mo57.5 ± 5229.5 ± 0.6
    After 6 mo32.6 ± 7.829.4 ± 0.6
IP-100.026*
    Before290 ± 175.3205.1 ± 37.9
    After 2 mo255.4 ± 105.7175.5 ± 12.5
    After 6 mo179.5 ± 13.7171.7 ± 5.8
  • a A linear mixed model with adjustment for age, gender, and sputum smear result was used. Data are presented as the means ± standard deviations. *, significant difference between the two groups (P < 0.05).