TABLE 1.

M. tuberculosis proteins tested for MHC class II peptide binding

Protein nameGene nameFunctional classification
10-kDa chaperonin GROES CAB01005Rv3418cVirulence, detoxification, adaptation
60-kDa chaperonin 2 P0A521Rv0440Virulence, detoxification, adaptation
Heat shock protein HSP CAA17343Rv0251cVirulence, detoxification, adaptation
Heat shock protein HSPX CAA17245Rv2031cVirulence, detoxification, adaptation
MCE family protein MCE1A YP_177701Rv0169Virulence, detoxification, adaptation
Possible hemolysin CAA16235Rv3922cVirulence, detoxification, adaptation
Possible hemolysin-like protein CAA17201Rv1085cVirulence, detoxification, adaptation
3-Oxoacyl-[acyl-carrier protein] synthase 2 KASB CAA94642Rv2246Lipid metabolism
Biotinylated protein TB7.3 CAB08316Rv3221cLipid metabolism
M. Bovis acyl- coenzyme A synthase gene; U75685Lipid metabolism
M. Bovis mycocerosic acid synthase gene M95808Lipid metabolism
Putative cyclopropane-fatty-acyl-phospholipid synthase UFAA1 NP_854118Rv0447cLipid metabolism
Secreted antigen 85-B FBPB (85B) CAB10044Rv1886cLipid metabolism
Alternate RNA polymerase sigma factor SIGF CAB07069Rv3286cInformation pathways
Probable 50S ribosomal protein L7/L12 RPLL CAB07109Rv0652Information pathways
RNA polymerase beta subunit AAA21416Rv0667Information pathways
RNA polymerase beta′ subunit AAA21417Rv0667Information pathways
10-kDa culture filtrate antigen ESXBRv3874Cell wall and cell processes
Immunogenic protein MPT63 CAB06500Rv1926cCell wall and cell processes
Cell surface lipoprotein MPT83 CAB08316Rv2873Cell wall and cell processes
Conserved hypothetical protein TB9.8 CAD93159Rv0287Cell wall and cell processes
ESAT-6-like protein ESXQ CAA16102Rv3017cCell wall and cell processes
Immunogenic protein MPT64 CAA98382Rv1980cCell wall and cell processes
Lipoprotein LPQH precursor P0A5J0Rv3763Cell wall and cell processes
Low-molecular-weight protein antigen 7 ESXH TB10.4 CAA17363Rv0288Cell wall and cell processes
Low-molecular-weight T-cell antigen TB8.4NP_215690Rv1174cCell wall and cell processes
Major secreted immunogenic protein CAA98373Rv2875Cell wall and cell processes
Periplasmic phosphate-binding lipoprotein PSTS1 YP_177770Rv0934Cell wall and cell processes
Periplasmic phosphate-binding lipoprotein PSTS2 YP_177769Rv0932cCell wall and cell processes
Periplasmic phosphate-binding lipoprotein PSTS3 YP_177768Rv0928Cell wall and cell processes
Probable cutinase precursor CFP21 NP_216500Rv1984cCell wall and cell processes
Probable lipoprotein LPRJ CAB10947Rv1690Cell wall and cell processes
Putative ESAT-6-like protein ESXN YP_177838Rv1793Cell wall and cell processes
Secreted ESAT-6-like protein ESXR CAA16104Rv3019cCell wall and cell processes
6-kDa early secretory antigenic target ESXA(ESAT-6) CAE55648Rv3875Cell wall and cell processes
PE family protein CAE55335Rv0916cPE/PPE
PPE family protein CAE55371Rv1196PE/PPE
PPE family protein YP 177963Rv3347cPE/PPE
PPE family protein CAE55334Rv0915cPE/PPE
PPE family protein CAE55489Rv2430cPE/PPE
PPE family protein CAE55504Rv2608PE/PPE
Secreted l-alanine dehydrogenase ALD CAA15575Rv2780Intermediary metabolism and respiration
Possible glycosyltransferase CAB05418Rv2958cIntermediary metabolism and respiration
Possible glycosyltransferase CAB05419Rv2957Intermediary metabolism and respiration
Probable isocitrate dehydrogenase CAA17111Rv3339cIntermediary metabolism and respiration
Probable isocitrate dehydrogenase CAA16247Rv0066cIntermediary metabolism and respiration
Probable molybdopterin-guanine dinucleotide biosynthesis protein CAA16030Rv2453cIntermediary metabolism and respiration
Probable serine protease PEPA CAB09453Rv0125Intermediary metabolism and respiration
Probable serine protease PEPD CAA17582Rv0983Intermediary metabolism and respiration
Possible glycosyltransferase CAB05415Rv2962cIntermediary metabolism and respiration
MTB48 AAK31576Unknown
MTB81Unknown
Transmembrane serine/threonine-protein kinasE D PKND NP_215446Rv0931cRegulatory proteins
Two-component transcriptional-regulatory protein DEVR NP_217649Rv3133cRegulatory proteins
Conserved hypothetical protein CFP17 CAB01474Rv1827Conserved hypotheticals
Conserved hypothetical protein TB16.3CAD97060Rv2185cConserved hypotheticals
Conserved hypothetical protein TB18.5CAD93033Rv0164Conserved hypotheticals
Hypothetical protein NP_217139Rv2623Conserved hypotheticals
Hypothetical protein NP_217142Rv2626cConserved hypotheticals
Iron-regulated conserved hypothetical protein CAB08889Rv1636Conserved hypotheticals
Conserved hypothetical protein CAB08634Rv2629Conserved hypotheticals