TABLE 3.

Comparison of immune responses in mice injected with various dosages of Vi-DT C4a

DoseGM of IgG anti-Vi (95% CI), 2 wk after indicated injectionsb
1st2nd
Vi-DT C4
    2.5 μg13.24 (9.36-18.73)24.04 (11.07-.52.19)
    1.25 μg8.81 (6.84-11.35)17.65 (8.89-35.04)
    0.5 μg4.36 (2.12-5.11)4.33 (1.83-5.88)
Saline0.02 (0.02-0.02)NDc
  • a Female mice (6 weeks old; 10/group) were injected s.c. twice, 4 weeks apart, with Vi-DT conjugate C4 at various dosages (2.5 μg, 1.25 μg, and 0.5 μg of Vi per injection as Vi-DT). Serum samples were collected 2 weeks after each injection. IgG anti-Vi was assayed by ELISA.

  • b 2.5 μg versus 1.25 μg, 13.24 versus 8.81, P < 0.05 and 24.04 versus 17.65, P > 0.3; 2.5 μg versus 0.5 μg, 13.24 versus 4.36 and 24.04 versus 4.33, P < 0.001; 1.25 μg versus 0.5 μg, 8.81 versus 4.36, P < 0.002 and 17.65 versus 4.33, P < 0.003.

  • c ND, not done.