TABLE 1.

LIPS performances of top 10 HHV-8 antigens for KS diagnosis

AntigenAUCaP valuebSensitivitycSpecificityc
K8.1-Δ40.960.001113/160/6
K8.1-Δ10.920.002812/160/6
LANA-Δ30.910.005213/160/6
v-Cyclin0.890.006812/160/6
ORF650.840.010510/160/6
LANA-Δ20.820.021210/160/6
K8.1-Δ20.810.027112/160/6
ORF520.580.56693/161/6
ORF470.550.76671/160/6
LANA-Δ10.520.85301/160/6
• a ROC as determined by the area under the curve (AUC).

• b The P value was calculated using the Mann-Whitney U test.

• c For LIPS, the cutoff limit for calculating the sensitivity and specificity for each antigen was derived from the value of the mean plus 5 SD of the six control samples.