TABLE 1.

Normalized values for early pulmonary cytokine responses in vaccinated mice following an aerosol infection with M. tuberculosis

CytokineFold expression level (mean ± SEM) induced by vaccinea
Day 7bDay 10Day 14b
BCGΔsecA2SD1 DNA
Gdf32.2 ± 0.47.7 ± 1.89.8 ± 4.16.7 ± 0.9
IFN-γ2.6 ± 0.57.3 ± 2.08.3 ± 2.42.5 ± 0.86.8 ± 1.5
IL-72.3 ± 0.42.0 ± 0.2
IL-216.5 ± 2.07.9 ± 0.811.5 ± 3.0
IL-43.4 ± 0.82.9 ± 0.82.8 ± 0.7
IL-17f24.1 ± 1213.0 ± 8.23.7 ± 0.2
IL-277.2 ± 2.24.8 ± 0.24.2 ± 1.6
IFN-β4.8 ± 1.6
IL-1b2.3 ± 0.2
TNF-α2.2 ± 0.1
Gdf100.3 ± 0.05c0.3 ± 0.10.4 ± 0.1
Bmp30.3 ± 0.10.3 ± 0.1
IL-110.3 ± 0.10.3 ± 0.1
  • a Each reported value represents the mean increase (or decrease) in cytokine expression (relative to the level for naïve controls) ± the standard error of the mean for four to six experiments. “Day” refers to the number of days after the low-dose aerogenic infection with M. tuberculosis Erdman.

  • b Only BCG reactions were measured on this day.

  • c Normalized values of <1 represent expression levels that are downregulated relative to levels for naïve controls.