TABLE 2.

Presence of cytokines and growth factors in vaginal mucosa, urine, and serum

Cytokine/growth factorMean concn in pg/ml (95% CI) or no. of samples above assay sensitivity limit/total no. of samples (%) ina:
Vaginal swabUrineSerum
Control groupUTI groupControl groupUTI groupControl groupUTI group
IL-1β45 (0.4-90)8.9 (3.2-15)2/17 (12)4/22 (18)NDbND
9/17 (53)13/21 (62)NDND
IL-29/17 (53)1/21 (4.8)c1/17 (5.9)1/22 (4.5)21 (16-26)21 (17-26)
IL-47/17 (41)8/21 (38)1/17 (5.9)2/22 (9.1)10/17 (59)17/22 (77)
IL-65/17 (29)2/21 (9.5)2/17 (12)3/22 (14)5.9 (2.5-9.3)6.0 (3.5-8.5)
7/17 (41)10/22 (46)
IL-8732 (210-1,254)361 (148-574)36 (16-55)91 (0-234)24 (0-61)14 (4.8-24)
6/17 (35)15/22 (68)
IFN-γ6/17 (35)5/21 (24)6/17 (35)7/22 (32)14 (10-17)20 (11-30)
IL-101/17 (5.9)NDNDND1/17 (5.9)2/22 (9.1)
IL-12NDNDNDNDND2/22 (9.1)
IL-13NDNDNDNDND2/22 (9.1)
IL-15NDNDNDND1/17 (5.9)2/22 (9.1)
IL-178/17 (47)8/22 (36)NDND1/17 (5.9)4/22 (18)
PDGF-bb16 (3.7-29)5.6 (2.6-8.7)2.9 (1.6-4.2)2.5 (1.9-3.1)8,706 (6,730-10,683)9,762 (8,358-11,166)
bFGF1/17 (5.9)1/22 (4.5)2/17 (12)3/22 (14)ND1/22 (4.5)
MCP-110/17 (59)3/22 (14)c41 (29-52)31 (22-40)4/17 (24)6/22 (27)
TNF-α6/17 (35)5/21 (24)NDND11 (0-23)22 (0-47)
2/17 (12)5/22 (23)
VEGF1,118 (21-2,214)320 (98-542)c200 (95-304)168 (112-223)160 (101-219)159 (120-198)
TGF-β3.0 (1.9-4.0)3.8 (2.3-5.3)10.2 (5.7-15)9.9 (6.8-13)5.5 (4.3-6.7)6.1 (4.2-8.1)
  • a The values represent mean concentrations(95% CI) or prevalence of samples above the assay sensitivity limit(% positive), depending on whether most of the samples were above or below the limit, respectively. Both sets of values are given where relevant.

  • b ND, not detected; i.e., the concentration was below the lower limit of assay sensitivity in all samples.

  • c The concentrations were significantly different between UTI and control subjects at the 99% confidence level.