TABLE 1.

Bacterial burden in BALB/c mice challenged with Y. pestisa

GroupbY. pestis count (CFU/ml) at 3 days
BloodLiverLungsSpleen
Control3.4 × 105
Control7 × 1063.2 × 1071.3 × 1068.2 × 107
Control2.2 × 1032.1 × 1041.1 × 1062.1 × 104
Control6 × 1026 × 1052.8 × 1058.4 × 105
Control9.6 × 1072.1 × 1079.8 × 1082.1 × 109
Flagellin-F1-V0000
Flagellin-F1-V0000
Flagellin-F1-V0000
Flagellin-F1-V0000
Flagellin-F1-V0000
Flagellin-F1-V0000
  • a Groups of five mice each were given PBS or 10 μg flagellin-F1-V on two occasions and were then challenged with approximately 150 MTD50s of Y. pestis i.n. After 3 days, the mice were killed and the numbers of CFU in the blood, liver, lungs, and spleen were determined.

  • b Each line represents the results from a single mouse (PBS or flagellin-F1-V treated).