TABLE 1.

Effect of maternal pneumococcal or staphylococcal antibodies on S. aureus or S. pneumoniae colonizationa

Colonization and antibodybPrevalence (MFI) of S. aureus or S. pneumoniae in swabsc taken at:
1.5 mo6 moAt least two times in the first year
S. aureus colonization
    Maternal pneumococcal antibodies
        BVH-30.91 (0.74-1.11)0.89 (0.69-1.15)0.89 (0.70-1.13)
        PspC1.02 (0.86-1.21)0.95 (0.78-1.16)0.92 (0.76-1.12)
        PdBD0.82 (0.59-1.13)0.78 (0.55-1.11)0.63 (0.41-0.98)*
        Eno0.79 (0.50-1.25)0.77 (0.28-2.10)0.03 (0.00-9.10)
        Hyal0.94 (0.75-1.19)0.93 (0.72-1.21)0.74 (0.51-1.08)
        IgA1 protease1.00 (0.75-1.31)1.00 (0.73-1.38)0.97 (0.70-1.35)
        NanA†0.85 (0.70-1.03)0.94 (0.77-1.15)0.92 (0.74-1.14)
        PLY0.94 (0.76-1.15)0.95 (0.78-1.17)0.94 (0.75-1.18)
        PpmA0.95 (0.78-1.15)0.81 (0.61-1.09)0.87 (0.66-1.15)
        PsaA0.94 (0.82-1.09)1.00 (0.85-1.18)0.89 (0.73-1.07)
        PspA1.01 (0.86-1.18)0.77 (0.59-1.00)*0.80 (0.62-1.02)
        SlrA1.42 (0.63-3.23)0.81 (0.25-2.62)1.72 (0.60-4.98)
        SP01891.80 (0.26-12.40)
        SP0376†0.78 (0.46-1.32)0.96 (0.53-1.72)1.01 (0.59-1.72)
        SP10031.02 (0.80-1.31)0.75 (0.54-1.04)0.90 (0.68-1.18)
        SP1633†1.14 (0.77-1.68)1.04 (0.82-1.32)1.01 (0.78-1.30)
        SP1651†1.08 (0.84-1.38)0.71 (0.33-1.55)0.52 (0.16-1.68)
S. pneumoniae colonization
    Maternal staphylococcal antibodies
        ClfA0.84 (0.55-1.29)0.99 (0.77-1.27)1.01 (0.75-1.38)
        ClfB†0.99 (0.85-1.16)0.95 (0.84-1.08)0.99 (0.85-1.16)
        SasG†0.99 (0.92-1.07)1.03 (0.98-1.07)0.99 (0.92-1.06)
        IsdA0.42 (0.13-1.39)1.14 (0.81-1.60)1.04 (0.66-1.64)
        IsdH1.00 (0.62-1.62)1.09 (0.79-1.51)1.18 (0.79-1.77)
        FnbpA1.05 (0.48-2.30)0.96 (0.54-1.69)0.67 (0.30-1.50)
        FnbpB†0.94 (0.70-1.26)1.11 (0.96-1.29)1.03 (0.94-1.14)
        SdrD†0.89 (0.61-1.31)0.99 (0.89-1.09)0.66 (0.34-1.31)
        SdrE0.49 (0.17-1.400.49 (0.24-1.00)0.42 (0.14-1.20)
        SEA†0.99 (0.78-1.26)1.01 (0.86-1.19)1.17 (0.99-1.39)
        SEB0.88 (0.70-1.12)0.92 (0.77-1.10)0.85 (0.66-1.10)
        SEI0.95 (0.54-1.76)1.07 (0.70-1.65)0.93 (0.49-1.76)
        SEM†0.97 (0.86-1.10)1.01 (0.95-1.07)0.97 (0.87-1.09)
        SEO†1.09 (0.83-1.45)0.75 (0.51-1.11)0.70 (0.36-1.33)
        SEQ†0.98 (0.89-1.08)1.02 (0.99-1.05)1.03 (0.99-1.07)
        TSST-11.08 (0.90-1.31)0.95 (0.84-1.08)1.02 (0.87-1.19)
        SCIN0.92 (0.72-1.18)0.93 (0.80-1.08)0.89 (0.75-1.06)
        Efb0.93 (0.72-1.21)0.78 (0.61-0.99)*0.86 (0.66-1.11)
        CHIPS1.04 (0.79-1.36)0.84 (0.69-1.02)0.96 (0.77-1.21)
  • a Swabs were taken from the infants when the infants were 1.5 and 6 months old. The values in the table are median fluorescence intensities (MFIs); the values in parentheses are ranges. Using binary logistic regression analyses, differences in colonization prevalence were assessed per MFI unit. All MFI values were divided by 1,000, except for the antibodies with a † symbol, the MFI values for these antibodies were divided by 100. There were swabs missing at 1.5 months (n = 17), 6 months (n = 8), and 14 months (n = 7).

  • b Antibodies to the following 17 pneumococcal protein antigens were used: PspC (CbpA), choline-binding protein A; Eno, enolase; Hyl, hyaluronidase; IgA1 protease, immunoglobulin A1 protease; NanA, neuraminidase; PLY, pneumolysin; PdBD, a double mutant of pneumolysin; PmpA, putative proteinase maturation protein A; PsaA, pneumococcal surface adhesin A; PspA, pneumococcal surface protein A; the pneumococcal histidine triad (Pht) family (BVH-3 and SP1003); SlrA, streptococcal lipoprotein rotamase; SP, Streptococcus pneumoniae proteins; SP0189 (hypothetical protein), SP0376 (response regulator, intracellular location), SP1633 (response regulator, intracellular location) and SP1651 (thiol peroxidase, intracellular location). Antibodies to the following 19 staphylococcal proteins were used: CHIPS, chemotaxis inhibitory protein of S. aureus; ClfA and ClfB, clumping factors A and B, respectively; Efb, extracellular fibrinogen-binding protein; FnbpA and FnbpB, fibronectin-binding proteins A and B, respectively; IsdA and IsdH, iron-responsive surface determinants A and H, respectively; Sas, S. aureus surface protein; SCIN, staphylococcal complement inhibitor; SdrD and SdrE, serine-aspartate repeat proteins D and E, respectively; SEA, SEB, SEI, SEM, SEO, and SEQ, staphylococcal enterotoxins A, B, I, M, O, and Q, respectively; TSST-1, toxic shock syndrome toxin 1.

  • c Values that we consider statistically significantly different from basic prevalence values are indicated as follows: *, P value of 0.05.