IFN-γ and IL-10 production in PBMC cultures from pulmonary TB patients and healthy subjects

Subject(s)Cytokine production induced by indicated antigenIFN-γ/IL-10 production ratiobTB form
IFN-γ (pg/ml)aIL-10 (pg/ml)a
M. tuberculosisM. vaccaeCWSM. tuberculosisM. vaccaeCWSM. tuberculosisM. vaccaeCWS
TB patients
Healthy subjects (median)61.520.610.7101.357.879.7
  • a Minimum detectable concentrations were 2 pg/ml for IFN-γ and 0.5 pg/ml for IL-10.

  • b Ratios are the average IFN-γ values divided by the IL-10 value for each individual (5).

  • c Median levels of CWS-induced cytokines were significantly increased compared to those produced by M. vaccae (*, P < 0.05). Median levels of M. tuberculosis-induced cytokines were higher than those produced by M. vaccae (&, P < 0.001) or CWS (¶, P < 0.001), measured using the two-tailed Wilcoxon signed rank test.