TABLE 2.

GMCs of anti-LOS L11 ELISA IgG levels and anti-NadA IgG levels in Ethiopian MenA patient and control seraa

Parameter and age group (in yr)Ethiopian patientsEthiopian controlsNorwegian controls
Acute phaseEarly convalescent phaseLate convalescent phase
GMC (range)nGMC (range)nGMC (range)nGMC (range)nGMC (range)n
LOS IgG (AU/ml)
    All ages24.6 (0.8-135)6346.7 (8-143)4136.1 (11-281)3328.8 (4-232)1111.5 (1-5)37
    0.5 to ≤29.8 (8-12)225151.2 (25-105)214.0 (5-51)190
    >2 to ≤618.8 (2-53)1038.5 (15-136)834.6 (17-74)421.9 (8-232)170
    >6 to ≤1531.0 (3-135)2640.8 (8-143)1731 (13-68)1541.3 (16-81)211.5 (1-5)37
    >1523.2 (1-52)2562.8 (31-140)1541.8 (11-281)1235.1 (4-153)540
NadA-IgG (OD U/ml)b
    All ages0.26 (0.11-0.86)620.37 (0.13-1.20)420.28 (0.05-1.23)340.16 (0.05-0.34)300.09 (0.05-0.15)10
    0.5 to ≤20.11 (0.11-0.12)20.1310.18 (0.12-0.26)20.17 (0.12-0.34)100
    >2 to ≤60.24 (0.13-0.86)100.31 (0.15-0.62)80.26 (0.16-0.54)400
    >6 to ≤150.25 (0.14-0.70)260.33 (0.14-0.69)170.28 (0.15-1.23)150.18 (0.14-0.23)100.09 (0.05-0.15)10
    >150.31 (0.13-0.73)230.49 (0.20-1.2)160.31 (0.05-0.70)130.13 (0.05-0.34)100
  • a n, number of sera analyzed.

  • b Anti-LOS IgG antibody concentrations were calculated using a four-parametric fitting model for standard curve dilutions of a positive serum assigned to 1,000 AU/ml, which is assumed to correlate well with actual antibody concentrations. In contrast, the direct OD values of anti-NadA IgG binding in 1:100 dilution of sera do not correlate with antibody concentrations in a proportional manner.