TABLE 1.

Plasma concentrations of cytokines in PUUV-infected females and males during the acute phase of HFRSa

CytokineMean plasma concn ± SD (pg/ml) in:P value
Females (n = 20)Males (n = 19)
IL-1β4.1 ± 4.72.1 ± 1.40.35
IL-1RA471 ± 4531,160 ± 1,5600.07
IL-225.1 ± 38.37.8 ± 11.80.11
IL-43.3 ± 5.80.5 ± 1.20.20
IL-54.5 ± 8.53.3 ± 7.50.39
IL-622.1 ± 27.819.0 ± 18.20.76
IL-73.9 ± 3.33.4 ± 3.20.48
IL-814.2 ± 17.348.3 ± 85.80.02
IL-9367 ± 653141 ± 2070.02
IL-1022.2 ± 22.547.9 ± 55.90.18
IL-12 (p70)24.1 ± 46.117.0 ± 67.10.13
IL-133.1 ± 6.01.0 ± 1.90.37
IL-155.7 ± 8.63.5 ± 5.40.66
IL-1727.1 ± 62.31.0 ± 4.20.11
Eotaxin74.5 ± 41.166.9 ± 22.40.94
FGF-266.9 ± 71.713.4 ± 16.20.004
G-CSF57.9 ± 18613.8 ± 15.10.77
GM-CSF54.9 ± 82.510.9 ± 16.20.006
IFN-γ62.6 ± 89.7201 ± 6990.71
IP-102,880 ± 5,43010,700 ± 15,6000.007
MCP-1233 ± 360302 ± 2560.07
MIP-1α3.3 ± 8.90.0 ± 0.00.42
MIP-1β83.3 ± 56.2124 ± 84.30.07
PDGF-BB626 ± 1390549 ± 8560.37
RANTES5,710 ± 12,50010,400 ± 16,9000.80
TNF18.1 ± 33.95.4 ± 12.50.17
VEGF38.8 ± 27.241.0 ± 26.60.70
  • a Cytokines for which significant sex differences were observed are indicated in bold. P values were determined with the Mann-Whitney U test.