TABLE 4.

Cytokine levels in incident and persistent HPV infections compared with negative control subjects

CytokineNegative control groupa (n = 34)Incident HPV infection groupb (n = 15)Persistent HPV infection groupc (n = 18)
Median cytokine level, pg/ml (IQR)dNo. of samples in which cytokine was undetectableeMedian cytokine level, pg/ml (IQR)dNo. of samples in which cytokine was undetectableeMedian cytokine level, pg/ml (IQR)dNo. of samples in which cytokine was undetectablee
Proinflammatory
    IL-1β263 (117, 609)2171 (102, 566)0138 (85, 446)0
    IL-63,117 (1,111, 4,957)01,699 (977, 2,315)02,779 (1,474, 4,056)0
    IL-813,338 (6,294, 24,165)116,666 (5,783, 28,439)09,838 (6,140, 26,571)0
Immunoregulatory
    IFN-γ5 (2, 9)03 (2, 4)13 (1, 7)0
    IL-229 (15, 39)019 (12, 35)029 (17, 39)0
    IL-411 (5, 26)98 (5, 17)213 (10, 17)3
    IL-56 (2, 9)04 (2, 7)15 (3, 7)0
    IL-1043 (15, 81)046 (29, 73)031 (21, 43)0
    IL-12121 (71, 301)095 (52, 123)093 (58, 160)0
    IL-1344 (20, 91)2013 (5, 30)819 (13, 57)11
  • a HPV negative at the cytokine test visit and all prior study visits.

  • b HPV positive at the cytokine test visit but HPV negative at all study visits prior to the cytokine test visit.

  • c HPV positive (same type) at both the cytokine test visit and the study visit 4 months prior.

  • d Median (interquartile range [IQR]) cytokine levels (picograms per milliliter) of samples in which cytokine was detected.

  • e Number of samples in which cytokine was undetectable (included as lowest rank in Wilcoxon rank sum test).