TABLE 3.

Significant covariates of cytokine levels in cervical mucusa

CytokineOdds ratio (95% CI) fora
Continuous variablesbCategorical variablesc
Age at first intercourseDays since last intercourseCurrent yeast infection>5 WBCs/HPFd on wet-mount examinationCigarette smoking within last 24 he
Proinflammatory
    IL-1β0.33* (0.12, 0.94)
    IL-60.33* (0.12, 0.93)
    IL-81.52** (1.13, 2.04)4.82* (1.21, 19.2)
Immunoregulatory
    IFN-γ7.52* (1.36, 41.5)0.33* (0.11, 0.93)
    IL-2
    IL-4
    IL-50.99** (0.98, 1.00)9.80** (1.69, 56.8)
    IL-100.34* (0.12, 0.94)
    IL-126.02* (1.23, 29.6)
    IL-133.85* (1.13, 13.2)
  • a Proportional odds ratios (95% confidence intervals [CI]) of having higher quartiles of cytokine levels in a multinomial logistic regression model controlling for the variables shown as well as for race and days since LMP. *, P ≤ 0.05; **, P ≤ 0.01.

  • b For continuous variables, the odds ratio represents the change in odds of cytokines being in the higher quartile group versus the comparison group, associated with a 1-U change in the independent variable (e.g., 1 day for the variable days since last intercourse).

  • c For categorical variables, the odds ratio represents the change in the odds of cytokines being in the higher quartile group versus the comparison group, associated with the independent variable.

  • d WBC/HPF, white blood cells per high-power field.

  • e Patient report of smoking of one or more cigarettes within 24 h preceding study visit.