TABLE 1.

Performance of four serologic assays for leptospirosis in subject groups from an urban center with highly endemic transmission in Brazil

Assaya% Sensitivity (95% CI) for group in:% Specificity (95% CI) (n = 80)
Acute phase (n = 96)Acute phase (n = 72)bConvalescent phase (n = 50)c
MAT68.8 (58.4-77.6)45.8 (34.2-57.9)100.0 (91.1-100.0)100.0 (94.3-100.0)
ELISA BM79.2 (69.4-86.5)54.2 (42.1-65.8)96.0 (85.1-99.3)95.0 (87.0-98.4)
ELISA PB87.5 (78.8-93.1)66.7 (54.5-77.1)92.0 (79.9-97.4)87.5 (77.8-93.5)
DD80.0 (70.3-87.2)50.0 (37.9-62.1)84.0 (70.3-92.4)95.0 (87.0-98.4)
DS72.3 (62.0-80.8)32.9 (22.4-45.2)80.0 (65.9-89.5)100.0 (94.2-100.0)
  • a ELISA BM, EIE-IgM-Leptospirose(Bio-Manguinhos); ELISA PB, Leptospira IgM ELISA(PanBio); DS, Dip-S-Tick(PanBio); DD, LeptoTek Dri-Dot (bioMérieux); MAT, using a screening titer criterion of ≥1:100 in the microagglutination test.

  • b The acute-phase group included twenty-nine acute-phase patients and an additional 43 randomly selected patients; sera were collected <7 days from the onset of illness. CI, confidence interval.

  • c Convalescent-phase cases were randomly selected from the 96-acute-phase-patient group.