TABLE 1.

Comparison of EV-specific antibody titers elicited by a single immunization with Dryvax or MVAa

GroupType of immunizationRouteaDoseAntibody titer (log10 ± SD) against EV antigen:
A33RA56RB5R
1PBSi.m.NA0.10 ± 0.000.10 ± 0.000.10 ± 0.00
2Dryvaxi.d.1063.40 ± 0.423.25 ± 0.212.50 ± 1.27
3MVAi.m.1072.95 ± 0.213.11 ± 0.002.95 ± 0.21
4MVAs.c.1072.05 ± 0.212.95 ± 0.213.11 ± 0.42
5MVAi.d.1073.25 ± 0.643.11 ± 0.003.26 ± 0.21
6MVAi.m.1083.40 ± 0.003.41 ± 0.003.26 ± 0.21
7MVAs.c.1083.10 ± 0.003.11 ± 0.003.56 ± 0.21
8MVAi.d.1083.86 ± 0.212.95 ± 0.213.71 ± 0.00
  • a BALB/c mice were immunized with a single dose of PBS, Dryvax, or MVA at week 0 by the indicated routes of vaccination. Antisera were collected at week 6 and pooled, and the antibody levels against the indicated EV antigens were measured by ELISA. The results are the average of two independent immunization experiments in which each group contained three mice.