TABLE 2.

Comparison of EV-specific antibody titers elicited by single immunizations and prime-boost immunizationsa

GroupType of immunizationRouteDoseWk(s)Antibody titer (log10 ± SD) against EV antigen:
A33RA56RB5R
1PBSi.m.NA00.10 ± 0.000.10 ± 0.000.10 ± 0.00
2Dryvaxi.d.10602.80 ± 0.002.80 ± 0.002.50 ± 0.00
3Dryvaxi.d.10703.26 ± 0.213.11 ± 0.422.95 ± 0.64
4MVAi.d.1080, 33.11 ± 0.423.56 ± 0.214.01 ± 0.00
5MVAi.d.1080, 63.86 ± 0.213.86 ± 0.634.31 ± 0.42
  • a BALB/c mice were immunized with a single dose of PBS, Dryvax, or MVA at week 0 using indicated routes of vaccination. Mice in groups 4 and 5 received two doses of MVA given 3 weeks apart and 6 weeks apart, respectively. Mice in group 6 were immunized once with Dryvax by scarification at week 0. In groups 1 through 5, the results represent the average of two independent immunization experiments in which each group contained three mice.