TABLE 2.

Correlations between antibody activities in sera from MeNZB and MenBvac vaccinees measured by different antibody assays with the homologous and heterologous vaccine strainsa

Antibody assaysbSpearman rank order correlations coefficient
Homologous strainsHeterologous strains
MeNZB groupcMenBvac groupdMeNZB groupcMenBvac groupd
IgG OMV ELISA vs IgG ELISA with live bacteria0.8830.8810.8010.938
IgG OMV ELISA vs SBA assay0.7970.8370.6760.819
IgG OMV ELISA vs OPA assay0.8360.8950.8510.912
IgG OMV ELISA vs total IgG band intensity on blots0.7570.8330.5850.855
IgG with live bacteria vs total IgG band intensity on blots0.6150.9010.4740.788
IgG with live bacteria vs OPA assay0.8500.9020.8190.907
SBA assay vs IgG ELISA with live bacteria0.9020.8510.7990.797
SBA assay vs OPA assay0.8350.7990.7260.843
  • a All correlations were significant (P < 0.001).

  • b OMVs were the antigens in the ELISA and the immunoblotting assay; live meningococci were used in the remaining assays.

  • c Pre- and postvaccination sera from 24 individuals.

  • d Pre- and postvaccination sera from 26 individuals in all assays except for the blotting assay, which had 16 individuals.