TABLE 2.

Antibody responses after rBCG CON6 prime and rHIV-1 CON6 gp140 protein boost in BALB/c micea

Prime or boost immunogenExpressed insert formGeometric mean endpoint titer(s)b
BCG-PControl6,925
222empPasControl6,653
120secPasSecreted28,900*
140surPasSurface20,564**
BCG-DControl8,680
222empDanControl9,313
120secDanSecreted41,572**
140surDanSurface42,286**
CON6959
  • a The dose of rBCG was 107 or 106 CFU. The boost immunogen was CON6 gp140 with RiBi adjuvant.

  • b Anti-HIV-1 gp140 geometric mean titer (n = 5 mice). *, statistically significant (P < 0.01) compared to the control groups that were immunized with BCG-P or 222empPas; **, statistically significant (0.01 < P < 0.02) compared to the control groups that were immunized with BCG-D or 222empDan.