TABLE 3.

B. burgdorferi B31 VlsE-IR6 shortest immunodominant region

PeptideaSequencebNo. positive/total (%)c
B31-25(C)MKKDDQIAAAIALRGMAKDGKFAVK11/33 (33)*
B31-18MKKDDQIAAAIALRGMAK12/33 (36)
B31-17(C)MKKDDQIAAAIALRGMA13/33 (39)*†
B31-16aMKKDDQIAAAIALRGM8/33 (24)†
B31-16bKKDDQIAAAIALRGMA11/33 (33)
  • a The peptides correspond to the IR6 immunodominant regions of VlsE in B. burgdorferi sensu stricto.

  • b (C) is the cysteine appended for purposes of biotinylation. The Lyme disease panel used contained 33 acute-phase sera characterized by EM and culture positive.

  • c *, OR = 1.552; †, OR = 2.009.