TABLE 4.

Levels of serum IgG to antigens in OMVs from strain 44/76-SL measured on immunoblots before vaccination and after the third dose of MeNZB and MenBvaca

OMV antigenIgG binding intensityb (kAU) for MeNZB groupP for MeNZB groupIgG binding intensityb (kAU) for MenBvac groupP for MenBvac groupP for postresponse comparison
Prevaccination seraPostvaccination seraPrevaccination seraPostvaccination sera
Omp850 (0-8.7)3.6 (0-13.9)<0.0010 (0-7.7)7.3 (0-14.6)<0.001NS
FetA0.9 (0-26.4)1.8 (0-27.8)NS0 (0-27.8)0 (0-23.9)NSNS
PorA9.2 (4.2-27.7)13.2 (4.3-31.0)<0.0016.5 (1.4-23.8)13.4 (9.4-32.6)<0.001NS
PorB7.6 (0-21.4)8.0 (0-26.0)NS6.4 (2.2-27.2)16.2 (3.8-32.3)<0.001<0.001
FbpA0 (0-12.3)4.3 (0-17.9)<0.0010 (0-10.7)0 (0-21.4)0.031NS
RmpM2.9 (0.8-7.1)7.1 (2.6-32.7)<0.0012.5 (0-12.7)7.1 (0-22.6)<0.001NS
OpcA4.8 (1.6-13.7)6.8 (3.0-23.3)0.0014.3 (1.4-18.9)8.9 (3.6-22.2)<0.001NS
OpaJ1.7 (0-13.7)2.2 (0-14.3)NS0 (0-18.2)6.7 (0-20.1)<0.0010.01
NspANDdNDNDND
LPSc0 (0-15.2)5.1 (0-41.8)<0.0010 (0-5.8)9.4 (0-47.6)<0.001NS
  • a Pre- and postvaccination sera from 24 and 16 individuals receiving MeNZB and MenBvac, respectively, were analyzed.

  • b IgG binding intensities were obtained by scanning; the values are medians, with ranges given in parentheses. AUs were rounded off to the nearest 100 integer. NS, no significant difference.

  • c LPS antibody responses are the sums for the L3 and L8 bands.

  • d ND, not determined.