TABLE 3.

Cross-reactivity in sera from patients with HAV, HBV, or HCV infection in the HEV IgM and IgG ELISAs and after immunoblotting confirmationa

Test and infectionFrequency (%) of cross-reactivity with HEV Ig
Only IgMOnly IgGbIgM and IgGb
ELISA
    HAV2/23 (9)1/23 (4)1/23 (4)
    HBV1/20 (5)3/20 (15)0/20 (0)
    HCV6/58 (10)15/58 (26)*7/58 (12)*
Combined regimen
    HAV0/23 (0)0/23 (0)0/23 (0)
    HBV0/20 (0)4/20 (20)0/23 (0)
    HCV3/58 (5)5/58 (9)0/58 (0)
  • a In total, 23, 20, and 58 HAV, HBV, and HCV confirmed cases, respectively, were analyzed for cross-reactivity in the HEV serology according to the combined testing regimen. All patients were first screened with both the IgM and IgG HEV ELISAs. All IgM- and/or IgG-reactive samples were then tested in both the IgG and IgM immunoblot assays. The results of the immunoblot assay were considered conclusive irrespective of previous IgG or IgM responses detected in the ELISA.

  • b *, significantly different (P < 0.01) from the control group (results are shown in Table 1).