TABLE 2.

Antibody responses to CON6 envelope protein after recombinant M. smegmatis CON6 prime and recombinant HIV-1 CON6-gp140 protein boosta

PrimeExpressionBoostbGMTc
M. smegmatisControlCON6-gp140667
Empty pJH222ControlCON6-gp140560
pJH152-gp120Surface, full lengthCON6-gp140368
pJH153-gp120Intracellular, full lengthCON6-gp1405,164
pJH154-gp120Secreted, full lengthCON6-gp1407,211
pJH152-gp140CFSurface, full lengthCON6-gp140700
pJH222-gp140CFSurface, cleaved formCON6-gp1401,622
pJH154-gp140CFSecreted, cleaved formCON6-gp1404,498
CON6-gp140759d
  • a Dose of recombinant M. smegmatis, 108 or 109 CFU.

  • b CON6 gp140CF protein with RiBi adjuvant.

  • c GMT, anti-HIV-1 gp140 geometric mean titer (M. smegmatis-M. smegmatis-CON6-gp140CF) (n = 5).

  • d 1× CON6.