TABLE 1.

Characteristics of the cohorts of organ transplant recipients who did and did not develop cryptococcosis after transplantation

CharacteristicTotalPretransplantation sera from patientsaPosttransplantation sera from patientsa
CN−CN+CN−CN+
No. of subjects491015 (9)b1113 (9)b
No. of males1014511
Mean age (yr) (range)5144 (39-49)53 (37-64)53 (45-63)54 (22-65)
No. of patients with the indicated organ transplanted13 liver5 lung7 liver
6 lung6 liver4 kidney
4 kidney1 lung
1 heart1 heart
Prior rejection rate (%)c0266323
Primary immunosuppressive drug (no. of patients)Tacrolimus (10)Tacrolimus (15)Tacrolimus (8), tacrolimus + sirolimus (1), tacrolimus + azathioprine (2)Tacrolimus (13)
No. of patients with the indicated site infected with C. neoformans8 lung9 lung (includes 6 subjects also studied pretransplant)
2 lung + skin2 lung + CNS
1 bone1 CNS
1 skin1 CNS + skin
1 CNS
2 lung + CNS
Mean time to cryptococcosis (days) (range)d246 (37-476)533 (40-1,338)
  • a Pre- and posttransplantation sera were obtained from organ transplant recipients who developed cryptococcosis (CN+) and from those did not develop cryptococcosis (CN−) after transplantation.

  • b The nine subjects who were studied pre- and posttransplantation.

  • c Prior rejection is defined here as one or more episodes of rejection 6 months prior to the transplant.

  • d Time blood was drawn after transplant. For CN+ subjects, it is the length of time after the transplant before the cryptococcosis diagnosis; for CN− subjects, it is the same length of time or as close after transplantation as the time elapsed from transplantation in CN+ subjects.