TABLE 3.

Association between CD14 C-159T genotype and categorized number of AOM episodes according to ageb

GenotypeNo. (%) of subjects with the indicated no. of AOM episodesa
Total cohortParticipants aged
12 to 24 mo>24 mo
No AOM episodes≥1 AOM episodeNo AOM episodes≥1 AOM episodeNo AOM episodes≥1 AOM episode
CD14 CC17 (37)29 (63)3 (19)13 (81)14 (47)16 (53)
CD14 CT37 (48)40 (52)11 (41)16 (59)26 (52)24 (48)
CD14 TT18 (47)20 (53)9 (64)5 (36)9 (38)15 (62)
  • a Prospectively obtained data during 18 months of follow-up in children who did not receive pneumococcal vaccinations. P values for the comparison of numbers of individuals with 2 or 3 AOM episodes with numbers of individuals with ≥4 AOM episodes according to the three genotype groups by using chi-square analyses are 0.09 for the total cohort, 0.002 for participants 12 to 24 months of age, and 0.9 for participants >24 months of age. P values for the comparison of numbers of individuals with 2 or 3 AOM episodes with numbers of individuals with ≥4 AOM episodes according to the homozygous CC and TT genotypes by using chi-square analyses are 0.05 for the total cohort, 0.004 for participants 12 to 24 months of age, and 0.8 for participants >24 months of age. Age of control subjects at the start of the pneumococcal vaccine study.