TABLE 1.

CD4+ T-cell epitopes in ESAT-6 and CFP-10 proteins selected to be broadly recognized in patients with A-TB

ProteinPositionSequenceDR serological specificities covereda
ESAT-66-28WNFAGIEAAASAIQGNVTSIHSL1, 3, 4, 8, 11(5), 13(6), 52, 53
ESAT-666-78NALQNLARTISEA3, 8, 11(5), 13(6), 15(2), 52
CFP-1018-31FERISGDLKTQIDQ3, 5, 11(5), 52
CFP-1043-70GQWRGAAGTAAQAAVVRFQEAANKQKQE1, 3, 4, 7, 8, 11(5), 13(6), 15(2), 52
CFP-1074-86TNIRQAGVQYSRA3, 4, 7, 8, 11(5), 12(5), 13(6), 15(2)
  • a HLA class II alleles putatively able to recognize the selected ESAT-6 and CFP-10 peptides are listed according to serological specificity, i.e., the group of alleles recognized by the same allo-antisera used for low-resolution HLA typing. Where necessary, the serological HLA class II subgroup to which the HLA-DR allele that is putatively able to recognize the peptide belongs is shown in parentheses.