TABLE 1.

HLA class II allele group expression frequencies at DRB and DQB1 locia by HIV status

DRB allele groupPopulation frequency (%)No. (%) of individuals with the indicated allele groupbP valuec
HIV+ (n = 74)HIV (n = 55)
DRB1*0121.76 (8.1)16 (29.1)0.002
DRB1*02/1521.315 (20.3)12 (21.8)0.83
DRB1*0322.217 (23.0)12 (21.8)1.00
DRB1*0414.413 (17.6)7 (12.7)0.62
DRB1*079.27 (9.5)5 (9.1)1.00
DRB1*0814.210 (13.5)8 (14.5)1.00
DRB1*091.02 (2.7)0 (0.0)0.51
DRB1*106.13 (4.1)4 (7.3)0.46
DRB1*1135.525 (33.8)20 (36.4)0.85
DRB1*127.66 (8.1)4 (7.3)1.00
DRB1*1332.228 (37.8)16 (29.1)0.35
DRB1*140.51 (1.4)0 (0.0)1.00
DRB1*160.51 (1.4)0 (0.0)1.00
DRB3*0134.325 (33.8)19 (34.5)1.00
DRB3*0238.837 (50.0)18 (32.7)0.071
DRB3*0327.418 (24.3)16 (29.1)0.55
DRB4*0121.623 (31.1)9 (16.4)0.065
DRB5*0119.411 (14.9)12 (21.8)0.36
DRB5*020.51 (1.4)0 (0.0)1.00
DQB1*0214.914 (18.9)7 (12.7)0.47
DQB1*0339.228 (37.8)22 (40.0)0.86
DQB1*0425.822 (29.7)13 (23.6)0.12
DQB1*0521.513 (17.6)13 (23.6)0.51
DQB1*0647.731 (41.9)28 (50.9)0.37
DQB1 heterozygousd51.837 (52.1)29 (53.7)1.00
  • a The DQB1 allele group was not determined for four study participants (three HIV positive and one HIV negative; 2.6%) because of lack of a DNA sample.

  • b Totals do not add up to 100% at DRB1 and DRB3 loci due to heterozygosity and at DRB5 due to rounding.

  • c By Fisher's exact test. The boldfaced value is significant.

  • d Study participants whose DQB1 allele groups could not be typed due to lack of a DNA sample were excluded from calculation of population frequencies and from the comparisons.