TABLE 3.

Comparison of CD4+ cell counts and HIV-1 RNA loads by HLA class II allele group expression at DRB1 and DQB1 loci among HIV-infected Batswanaa

DRB1/DQB1 allele groupMedian CD4+ cell countb (no. of individuals) where the indicated allele group is:P valuec for CD4+ cell countMedian HIV-1 RNA loadd (no. of individuals) where the indicated allele group is:P valuec for HIV-1 RNA load
ExpressedNot expressedExpressedNot expressed
DRB1*01392 (6)348 (57)0.594.9 (5)4.7 (59)0.55
DRB1*02/15374 (12)344 (51)0.694.7 (13)4.8 (51)0.89
DRB1*03311 (13)390 (50)0.105.1 (17)4.7 (47)0.47
DRB1*04400 (11)346 (52)0.455.1 (9)4.8 (55)0.41
DRB1*07236 (5)365 (58)0.304.4 (5)4.8 (59)0.49
DRB1*08434 (10)317 (53)0.0913.3 (7)4.8 (57)0.011
DRB1*09317 (2)351 (61)0.724.8 (2)4.7 (62)0.94
DRB1*10314 (3)350 (60)0.854.4 (3)4.8 (61)0.94
DRB1*11379 (19)335 (44)0.744.8 (22)4.6 (42)0.41
DRB1*12366 (6)348 (57)1.003.7 (6)4.8 (58)0.21
DRB1*13379 (25)337 (38)0.814.7 (24)4.8 (40)0.92
DRB1*14448 (1)346 (62)0.514.6 (1)4.8 (63)0.77
DRB1*167 (1)350 (62)0.115.9 (1)4.7 (63)0.11
DQB1*02317 (12)385 (51)0.414.6 (10)4.8 (54)0.34
DQB1*03400 (21)319 (42)0.264.9 (21)4.7 (43)0.57
DQB1*04320 (19)365 (44)0.404.9 (20)4.8 (44)0.98
DQB1*05391 (12)344 (51)0.954.8 (12)4.7 (52)0.60
DQB1*06309 (28)379 (35)0.214.6 (29)4.8 (35)0.58
DQB1 unknown448 (3)346 (60)0.594.7 (3)4.8 (61)0.47
  • a CD4 cell count and plasma viral load data were unavailable for 11 and 10 HIV-positive study participants, respectively.

  • b Expressed as number of cells per cubic millimeter.

  • c By the Kruskal-Wallis test. Significant values are boldfaced.

  • d Expressed as log copies per milliliter.