TABLE 2.

Presence and experimental masses of the biomarker peak components of the MR score

BiomarkerProtein identityCalculated mass (Da)aObserved mass, Da (95% CI)No. of samples with peak present (%)
Amniocentesis (n = 48)Vaginal pool (n = 17)
Individual biomarkers
    P1HNP-23,377.03,378.0 (3,377.7-3,378.3)24 (50)16 (94)
    P2HNP-13,448.13,448.2 (3,447.6-3,448.8)22 (46)17 (100)
    P3Cal-C (S100A12)10,443.810,446.6 (10,444.4-10,448.7)14 (29)14 (82)
    P4Cal-A (S100A8)10,834.510,837.2 (10,832.6-10,841.9)16 (33)15 (88)
MR scores
    MR 0-2 (at least 2 of the P1-P4 peaks present)32 (66)2 (12)
    MR 3-4 (3 or 4 of the P1-P4 peaks present)16 (33)15 (88)
  • a The calculated mass is the theoretical mass reported by the Swiss-Prot database (www.expasy.ch) of the protein without posttranslational modifications.