TABLE 1.

Descriptive statistics and selected results of variance component modeling stratified by protocol and overalla

Study no.nAge (yr)LRNACD4PCD4/CD8 ratio$$mathtex$$\({\sigma}_{e}^{2}\)$$mathtex$$$$mathtex$$\({\sigma}_{b}^{2}\)$$mathtex$$δρicc(15)ρicc(25)
1527382.275.15240.630.24105.940.690.910.84
1902275.12N/A240.530.16108.360.690.940.89
3006142.72N/A230.590.28127.410.610.940.90
3382897.114.19280.610.0761.390.770.930.86
3771905.644.44280.720.2074.640.590.940.89
382904.094.89290.790.11112.630.740.950.89
All21483.414.83250.610.27104.290.630.930.87
  • a Abbreviations and symbols: n, number of patients in each study; LRNA, median log10 HIV RNA copy number; CD4P, mean study-specific CD4%; CD4/CD8, median ratio of CD4 count to CD8 count; $$mathtex$$\({\sigma}_{e}^{2}\)$$mathtex$$ and $$mathtex$$\({\sigma}_{b}^{2}\)$$mathtex$$, the intra- and interpatient variability; δ, relationship between error variability and magnitude of CD4% measurement; ρicc(15) and ρicc(25), repeatability of results at mean CD4% of 15% and 25%, respectively; N/A, not applicable.