TABLE 1.

Morbidity outcome by placental malaria status and predicted mean of antibody responses to seven peptides in infants from PM-positive and PM-negative mothersa

ParameterResults for infants whose mother was:P value
PM positivePM negative
Measure of morbidity
    No. of children5050
    No. of males (%)20 (20)21 (21)
    Mean no. of observations per child (SE)10.1 (0.22)9.82 (0.21)NS
    Mean age (mo) at first visit (SE)1.42 (0.07)1.37 (0.07)NS
    Mean age (mo) at last visit (SE)10.64 (0.19)10.6 (0.18)NS
    No. of episodes/total no. tested for:
        Fever (%)34/503 (6.8)36/491 (7.3)NS
        HB < 11 (%)342/494 (69.2)290/486 (59.7)<0.05
        HB < 8 (%)33/494 (6.7)13/486 (2.7)<0.05
        Parasitemia (%)78/501 (15.6)72/490 (14.7)NS
        Parasitemia and HB < 11 (%)67/503 (13.3)46/491 (9.4)NS
        Parasitemia and fever (%)18/503 (3.6)7/491 (1.4)<0.05
Antibody responses to epitopes for:b
    Infants 0 to 4 months of age
        PL876 (CSP)6.13 (0.21)6.21 (0.29)NS
        PL885 (RAP-1)6.21 (0.25)6.52 (0.25)NS
        PL887 (EBA-175)4.75 (0.27)5.15 (0.29)NS
        PL888 (MSP-2)6.52 (0.31)6.54 (0.22)NS
        PL889 (MSP-2)6.47 (0.24)7.22 (0.18)NS
        PL890 (EBA-175)6.88 (0.22)8.23 (0.19)<0.0035
        PL893 (EBA-175)6.55 (0.28)7.42 (0.26)NS
    Infants ≥4 to 12 months of age
        PL876 (CSP)6.10 (0.23)7.26 (0.26)<0.0035
        PL885 (RAP-1)6.21 (0.25)7.33 (0.19)<0.0035
        PL887 (EBA-175)4.88 (0.26)5.63 (0.34)NS
        PL888 (MSP-2)6.83 (0.26)7.57 (0.19)NS
        PL889 (MSP-2)6.54 (0.25)7.22 (0.18)NS
        PL890 (EBA-175)7.02 (0.20)8.71 (0.22)<0.0035
        PL893 (EBA-175)6.87 (0.22)8.28 (0.23)<0.0035
  • a NS, not significant; SE, standard error. Data on episodes were analyzed using SUDAAN software.

  • b Data on antibody responses show predicted log mean antibody units and standard errors (in parentheses). Bonferroni P values of <0.0035 were considered significant.