TABLE 2.

Relationship between affinity and antibody titer (ID50)

SubjectEpitopeRelationship between relative affinity and ID50aNo. of sera examinedr2
RTB71Log-linearb90.978
WTB71Exponentialc80.970
TB72Log-linear80.709
MTB71Log-linearc70.891
TB72Log-linear70.934
FTB23Log-lineard70.885
WiTB23Exponentiald70.865
TB71Log-linear70.747
STB71Log-linear70.515
ATB68Log-linear70.676
VeTB23Log-linear60.893
CTB78Log-linear60.603
TB71Log-linear50.669
HL4fLog-linear50.845
  • a A log-linear relationship indicates no change in affinity of the antibody, whereas an exponential relationship indicates affinity maturation during treatment.

  • b As shown in Fig. 5B.

  • c As shown in Fig. 5C.

  • d These two subjects had antibody levels within the range defined by healthy controls for three or four initial samples and then positive titers for later samples.

  • e Same individual as V71 in Fig. 5C.

  • f Monoclonal antibody L4 binds to the same epitope as ML34 but is an IgG antibody, and therefore analysis of the serum could be carried out at the same time as for the other IgG monoclonal antibodies.