TABLE 6.

Overall ELISA inhibition results and number of rabbits testing positive for antigen by a given day

DayNo. of rabbits ELISA positive/total no. of rabbits tested (% positive)aMean percent inhibition ± SEb (n)
C. albicans-infected rabbitsNegative control rabbitsC. albicans-infected rabbitsNegative control rabbits
One positive resultcTwo or more positive resultsdOne positive resultTwo or more positive results
00/14 (0)0/14 (0)0/19 (0)0/19 (0)5.3 ± 1.3 (14)2.4 ± 0.8 (19)
17/14 (50)e0/14 (0)1/18 (6)0/18 (0)16.3 ± 2.5 (14)e,f6.0 ± 2.0 (18)
212/14 (86)e7/14 (50)e2/18 (11)0/18 (0)25.1 ± 3.4 (14)e,f6.7 ± 1.9 (18)
313/14 (93)e13/14 (93)e4/19 (21)2/19 (11)34.4 ± 3.9 (14)e,f6.4 ± 2.0 (19)
411/11 (100)e10/11 (91)e1/17 (6)0/17 (0)40.6 ± 5.2 (11)e,f5.2 ± 1.3 (17)
55/5 (100)e5/5 (100)e1/3 (33)0/3 (0)37.3 ± 4.4 (5)e,g11.6 ± 7.7 (3)
  • a C. albicans-infected rabbits included those receiving C. albicans by the intravenous or intragastric route with evidence of dissemination to deep organs by positive culture; negative control rabbits included all uninfected rabbits, rabbits colonized with C. albicans intragastrically or intraurethrally, and rabbits intravenously infected with bacteria or fungi other than C. albicans.

  • b Mean percent ELISA inhibition ± SE compared to preinfection urine for the number of rabbits in parentheses (positive cutoff, 13.5%).

  • c Number of rabbits giving a positive result on a given day regardless of results obtained on other days.

  • d Number of rabbits giving a positive result on a given day and on at least one day before the given day.

  • e P < 0.01 or P < 0.001 compared to day 0 results.

  • f P < 0.01 or P < 0.001 compared to urine from negative control rabbits obtained on the day indicated.

  • g P < 0.05 compared to urine from negative control rabbits obtained on the day indicated.