TABLE 3.

Inhibition ELISA results for rabbits infected with C. albicans compared with rabbits colonized with C. albicans or infected with non-C. albicans Candida species or other infectious agents

OrganismRoute of administrationa% Inhibition ± SE (n)bBurdenc in:
KidneySpleenLiverBloodUrineFeces
C. albicans strain 36BIntravenous50.2 ± 5.1 (6)d8.734.545.672470355
Intravenouse41.9 ± 2.9 (3)f6.714.925.891720
Intragastricg32.9 ± 2.7 (3)h1.401.1500620NAi
Intragastricj4.8 ± 1.7 (3)00001142,141
Intraurethral0 ± 0 (4)0000230305
C. parapsilosisIntravenous6.5 ± 1.6 (6)2.4000000
C. tropicalisIntravenous5.8 ± 2.2 (4)6.483.864.4901,500570
C. kruseiIntravenous5.1 ± 1.8 (6)02.230000
A. fumigatusIntravenous9.1 ± 3.1 (3)3.283.153.22110
C. neoformansIntravenous7.5 ± 3.6 (6)2.262.792.110010
S. aureusIntravenous6.4 ± 2.0 (3)9.4702.191510,000190,000
  • a All intravenously infected rabbits were immunosuppressed unless otherwise noted.

  • b Mean percent ELISA inhibition ± SE for the number of experiments in parentheses compared with preinfection urine; specimens were collected on the day of necropsy (day 4) unless otherwise noted. Mean percent ELISA inhibition ± SE on day 0, 2.6 ± 0.4 (n = 48).

  • c Mean log CFU per gram (kidney, spleen, and liver), mean CFU per gram (feces), mean CFU per milliliter (blood and urine).

  • d P < 0.001 compared to inhibition by preinfection urine.

  • e Rabbits were not immunosuppressed before infection.

  • f P < 0.01 compared to ELISA inhibition by preinfection urine.

  • g Rabbits were colonized by intragastric administration, and organisms disseminated to peripheral organs.

  • h ELISA results for urine collected on day 3 after infection; P < 0.01 compared to ELISA inhibition by preinfection urine.

  • i NA, none available.

  • j Rabbits were colonized by intragastric administration, and organisms did not disseminate to peripheral organs.