TABLE 7.

Overall sensitivity, specificity, positive and negative predictive values, and efficiency of the inhibition ELISA by day of infection

Day% Sensitivity/specificity for:% PPV/NPVa for:% Efficiency for:
One positive resultbTwo or more positive resultscOne positive resultTwo or more positive resultsOne positive resultTwo or more positive results
00/1000/100100
150/940/10088/710/10075100
286/8950/10086/89100/728878
393/7993/8977/9487/948591
4100/94100/10092/100100/10096100
5100/67d100/10083/100100/10088100
Overalle83/9282/9784/9195/908992
  • a PPV, positive predictive value; NPV, negative predictive value.

  • b Calculations based on a single positive result on a given day regardless of results obtained on other days; day 0 urine was collected before infection.

  • c Calculations based on a positive result on a given day and on at least one additional positive result on a day before the given day.

  • d These results are artificially low because only three negative control rabbits were tested on day 5 and one of these gave a false positive result on day 5 only.

  • e Data based on a total of 166 urine specimens from 33 rabbits collected on days 0 through 5 from C. albicans-infected rabbits and all negative control rabbits.