TABLE 1.

Comparison of ELISA positivity and culture results for organs and other specimens from rabbits infected intravenously with C. albicans strain 36B during disease progressiona

Day and parameterELISA resultCulture result
BloodUrineFecesKidneysSpleenLiver
Day 0
    No. positive/total (% positive)b0/8 (0)0 (0)0 (0)0 (0)
    Inhibition level or organism burdenc
        Mean ± SE2.8 ± 2.1 (8)0 ± 0 (8)0 ± 0 (8)0 ± 0 (8)
        Range0-12.10-00-00-0
Day 1
    No. positive/total (% positive)3/8 (38)5/8 (63)6/8 (75)3/8 (38)
    Inhibition level or organism burdenc
        Mean ± SE15.7 ± 2.7 (8)0.6 ± 0.2 (8)51 ± 23 (8)73 ± 38 (8)
        Range8.2-27.30-10-2000-260
Day 2
    No. positive/total (% positive)8/8 (100)5/8 (63)8/8 (100)6/7 (86)
    Inhibition level or organism burdenc
        Mean ± SE29.4 ± 4.8 (8)0.6 ± 0.2 (8)145 ± 83 (8)173 ± 34 (7)
        Range16.7-52.60-110-7200-280
Day 3
    No. positive/total (% positive)8/8 (100)4/7 (57)8/8 (100)7/8 (88)4/4 (100)2/2 (100)2/2 (100)
    Inhibition level or organism burdenc
        Mean ± SE41.9 ± 4.1 (8)1.1 ± 0.6 (7)1,020 ± 700 (8)1,849 ± 732 (8)14.6 ± 6.4 (4)85 ± 85 (2)11.9 ± 11.1 (2)
        Range27.9-63.70-411-5,8000-6,4504.5-320.1-1700.8-23
Day 4
    No. positive/total (% positive)5/5 (100)2/5 (40)5/5 (100)6/6 (100)6/6 (100)3/3 (100)3/3 (100)
    Inhibition level or organism burdenc
        Mean ± SE46.9 ± 5.4 (5)0.6 ± 0.4 (5)1,950 ± 1,462 (5)2,235 ± 1,328 (6)475 ± 215 (6)0.7 ± 0.7 (3)2.4 ± 1.9 (3)
        Range30.8-64.70-28-9,70062-8,64082-1,5000.03-2.10.009-6.2
Day 5
    No. positive/total (% positive)3/3 (100)0/2 (0)3/3 (100)1/1 (100)6/6 (100)3/3 (100)3/3 (100)
    Inhibition level or organism burdenc
        Mean ± SE44.5 ± 3.5 (3)0 ± 0 (2)1,340 ± 658 (3)86 ± 0 (1)456 ± 259 (6)0.02 ± 0.01 (3)0.2 ± 0.1 (3)
        Range37.5-54.30-024-2,00086d17-1,7000.006-0.040.004-0.44
  • a Rabbits were infected intravenously on day 0 with 107 C. albicans strain 36B blastoconidia and necropsied on day 3, 4, or 5 after infection.

  • b Number (percentage) of rabbits with a positive urine ELISA antigen detection result or with a culture-positive organ or other clinical specimen.

  • c ELISA results are percent inhibition relative to preinfection urine. Culture results are numbers of CFU per milliliter (blood and urine) or per gram (wet weight) (organs and feces). Data are for the number of rabbits (given in parentheses as n). Organ data were multiplied by 10−6.

  • d Feces were not available for two of the three remaining rabbits.