TABLE 2.

Percentages of subjects with detectable cytokine markers

MarkerSubjects with detectable cytokine markersa
HIV seronegativeHIV seropositive
AllVL <400VL 400-10,000VL >10,000
n% Detectablen% Detectablen% Detectablen% Detectablen% Detectable
Unstimulated protein
    IL-213640.423540.04748.910642.58231.7
    IFN-γ14236.624433.25131.410834.38532.9
    IL-414219.024815.75223.111112.68515.3
    IL-614366.423365.74969.410560.07970.9
    TNF-αb14235.224046.74953.111046.48143.2
Stimulated protein
    IL-2c18148.132650.66363.514546.211849.2
    IFN-γ17683.532480.36484.414579.311579.1
    IL-417724.932319.86323.814520.011517.4
    IL-618094.432892.76392.114693.211992.4
    TNF-α17883.232684.76379.414686.311785.5
Unstimulated mRNA
    IL-213614.725015.25010.010818.59214.1
    IFN-γ13625.025227.85034.011029.19222.8
    IL-4d13624.325217.55024.011017.39214.1
    TNF-α13632.425234.55036.011037.39230.4
Stimulated mRNA
    IL-211453.519548.24647.88348.26648.5
    IFN-γ12152.920162.24658.78461.97164.8
    IL-411932.820132.84637.08428.67135.2
    TNF-α12143.820149.84656.58448.87146.5
  • a The number (n) and percentage of subjects with detectable cytokine markers are shown for HIV-seronegative and HIV-seropositive subjects. All HIV-seropositive subjects and HIV-seropositive subjects with viral loads (VL) of <400, 400 to 10,000, and >10,000 copies/ml were studied.

  • b The values (percentage of subjects) for HIV-negative and all HIV-positive groups and the values for HIV-negative subjects and HIV-positive subjects with viral loads of <400 copies/ml were significantly different (P = 0.03 by the chi-square test).

  • c The values (percentage of subjects) for HIV-negative subjects and HIV-positive subjects with no detectable virus were significantly different (P = 0.03 by the chi-square test).

  • d P = 0.04 by the Cochran-Armitage test for trends across all four groups.