TABLE 1.

Neutralizing activities of sera from two patients with severe type II EMC resistant to rIFN-α2aa

Patient no.Neutralization titer against:
rIFN-α2a(C)IFNLeIFN
1b950 ± 19063 ± 10NDc
1d486 ± 8030 ± 5ND
1e1379 ± 2987 ± 4<10
2b47 ± 11<10ND
2d1,300 ± 26087 ± 20ND
2e1,600 ± 39987 ± 2<10
  • a Sera for detection of neutralizing activity were collected before the injection of the different IFN-α preparations (see text for details). The data are expressed as the means ± standard deviations for three separate determinations.

  • b Serum was analyzed before the injection of rIFN-α2a.

  • c ND, not done.

  • d Serum was analyzed before the first injection of (C)IFN.

  • e Serum was analyzed before the first injection of LeIFN.