TABLE 3.

TCR Vβ family analysis in CD8 T cells in HIV-infected children by CDR3 length analysis and FC analysis

Patient no.PCRFC
SkewingClonal dominanceExpansionDepletion
14, 5.1, 18, 20, 22, 23, 24None9, 22None
22, 3, 4, 5.1, 5.2, 6, 7, 8, 13.1, 13.2, 14, 15, 16, 17, 18, 20, 21, 22, 232, 5.1, 5.2, 14, 16, 17, 182, 5.3, 7, 8, 13.6, 181, 13.1, 21.3
34, 8, 9, 11, 188, 11, 182, 8, 11, 18, 22, 2313.1, 20
41, 2, 3, 4, 6, 8, 9, 11, 13.2, 16, 20,None5.2, 5.3, 12, 21.3, 221, 2, 13.6, 14
58, 12, 16, 20, 21, 22, 23, 24202, 9, 20, 221, 3, 7, 21.3
61, 3, 11, 14, 18, 20, 21, 22, 23, 241, 3, 11, 18, 20, 21, 24None5.1
73, 4, 5.1, 5.2, 6, 7, 12, 18, 235.1, 5.2, 12, 182, 3, 5.3, 9, 11, 18None
84, 5.1, 22, 245.1, 225.1, 5.3, 9, 18, 223
95.1, 5.2, 8, 9, 15, 18, 23NoneNone5.1
101, 3, 4, 5.2, 9, 11, 13.2, 14, 15, 16, 17, 18, 21, 22, 2411, 155.1, 5.3, 9, 13.1, 183, 7, 20
111, 3, 5.1, 11, 14, 16, 18, 21, 22, 2311, 162, 5.3, 9, 11, 16, 18, 21.3, 227, 20
121, 4, 13.2, 21, 23, 2421, 249, 13.6, 223
131, 12, 20, 21, 23, 2412, 20, 21, 245.1, 12, 14, 221, 13.1
143, 4, 6, 5.1, 12, 13.2, 14, 17, 18, 20, 21, 22, 23, 243, 6, 13.25.1, 7, 12, 16, 23None
154, 8, 20, 21None2, 22, 233
162, 4, 12, 15, 18, 20, 22, 244, 12, 1516, 181, 3, 5.1, 7, 13.1, 14
171, 4, 8, 9, 11, 12, 13.1, 14, 15, 17, 18, 21, 22, 231, 9, 13.11, 5.3, 9, 11, 13.1, 185.1, 7, 8, 12, 20, 21.3
185.2, 6, 14, 15, 205.2, 155.2, 13.1, 16, 223
191, 2, 4, 6, 7, 12, 14, 13.2, 15, 16, 17, 18, 20, 21, 22, 23, 24None2, 14, 16, 17, 18, 22, 23None
203, 14, 18, 21, 233, 14, 185.2, 5.3, 9, 11, 18, 22, 231, 13.1, 14, 20, 21.3
212, 3, 4, 6, 9, 12, 13.2, 15, 16, 17, 18, 20, 21, 22, 23, 243, 6, 13.2, 17, 20, 21, 242, 13.1, 16, 20, 233, 7
223None2, 5.2, 13.1, 22None
Total no. of TCR Vβ families altered (no. of patients)202 (22)55 (22)97 (22)45 (22)