TABLE 3.

Genotype distribution in trauma patients with and without development of severe sepsis

ISS (no. of patients)PolymorphismGenotypeDevelopment of severe sepsis (n)POR [95% confidence interval]
YesNo
4-57 (70)TNF-α −308 G/ATNF1/TNF110360.76
TNF1/TNF2420
TNF-β NcO1TNFB2/TNFB29220.78, 0.01 (0.014)a11 [1.7-66.7] (13 [1.8-95.5])a
TNFB1/TNFB148
TNFB1/TNFB2126
Homozygousb (TNFB1/TNFB1, TNFB2/TNFB2)13300.00811 [1.92-66.1]
TNFB1/TNFB2126
>15 (58)TNF-α −308 G/ATNF1/TNF110280.59
TNF1/TNF2416
TNF-β NcO1TNFB2/TNFB29150.81, 0.007 (0.024)a12.6 [1.97-80.5]
TNFB1/TNFB148(10.5 [1.3-82.8])a
TNFB1/TNFB2121
Homozygous (TNFB1/TNFB1, TNFB2/TNFB2)13230.00811.87 [1.97-71.4]
TNFB1/TNFB2121
  • a The first value is for the comparison with TNFB1/TNFB1, and the second value is for the comparison with TNFB1/TNFB2. Values in parentheses are for the comparison of the TNFB1/B1 genotype with the TNFB1/B2 genotype.

  • b Patients homozygous for the allele TNFB1 or TNFB2.