TABLE 3.

Effect of depletion of CD4+ and CD8+ T cells on control of growth of M. tuberculosis H37Ra in whole blood cultures of 24- and 96-h durationsa

Cells type depletedEffect of T-cell depletion (in Δlog10 CFU) of control of M. tuberculosis growth in:
PPD+ donors (n = 8)PPD donors (n = 5)
At 24 hPAt 96 hPAt 24 hPAt 96 hP
None−0.83 ± 0.4−0.78 ± 0.4−0.66 ± 0.3−0.68 ± 0.3
CD4−0.68 ± 0.30.1−0.61 ± 0.40.2−0.59 ± 0.30.8−0.50 ± 0.40.2
CD8−0.63 ± 0.30.03−0.61 ± 0.30.2−0.61 ± 0.30.9−0.41 ± 0.40.06
CD4 and CD8−0.60 ± 0.30.009−0.43 ± 0.40.001−0.62 ± 0.30.9−0.49 ± 0.40.2
    P (overall)0.0090.0030.80.07
  • a Significance was determined by RM ANOVA and Tukey's test. PPD+, PPD-positive; PPD, PPD-negative.