TABLE 2.

Effect of methylprednisolone (50 μg/ml) or pentoxifylline (1 mM) on control of M. tuberculosis in 96-h whole blood cultures in subjects grouped according to tuberculin skin test statusa

Drug usedEffect of drugs on control of growth of M. tuberculosis strain
H37Ra in:MP-28 in:
PPD+ donors (n = 5)PPD donors (n = 3)PPD+ donors (n = 6)PPD donors (n = 7)
Mean ± SDPMean ± SDPMean ± SDPMean ± SDP
No drug−0.27 ± 0.20.25 ± 0.21.02 ± 0.10.92 ± 0.1
Methylprednisolone−0.10 ± 0.10.030.19 ± 0.20.91.04 ± 0.10.61.02 ± 0.10.1
Pentoxifylline−0.12 ± 0.10.050.06 ± 0.20.51.08 ± 0.10.20.95 ± 0.10.3
    P (overall)0.020.50.30.1
  • a Data indicate Δlog CFU. Overall significance was determined by RM ANOVA. Comparisons to control cultures without added drug were performed using Tukey's test. PPD+, PPD positive; PPD, PPD negative.