TABLE 2.

Levels of the innate mediators of the immune system in blood samplesb

Age group and mediatorAcute stage (day 2)Convalescence (day 7)Convalescence (day 30)Healthy controls
Adults
    PGE2 (pg/ml)1,700 (780-3,890)590 (480-4,700)690 (390-2,440)1,770 (1,060-8,620)
    PGF (pg/ml)1.36 (0.83-2.38)0.75 (0.43-1.63)0.90(0.66-1.40)1.27 (0.48-1.55)
    LTB4 (pg/ml)476 (208-1,000)†‡309 (260-493)‡179 (35-850)132 (118-265)
    Lf (ng/ml)505 (288-772)‡434 (355-562)321 (212-460)306 (216-738)
    SOD (sp act [U/mg of protein])1.20 (1.16-1.25)‡0.063 (0.058-0.067)‡0.048 (0.036-0.064)0.024 (0.019-0.03)
    MPO (sp act [U/mg of protein])0.02 (0.014-0.026)0.01 (0.006-0.03)0.023 (0.016-0.033)0.02 (0.005-0.03)
    NO˙a metabolites (nmol/ml)184 (144-323)*†‡58 (47-70)37 (32-60)38 (32-80)
    CRP (mg/dl)4.1 (2.3-7.5)*†‡2.0 (0.5-3.2)0.85 (0.5-2.4)UDc
Children
    PGE2 (pg/ml)1,103 (740-1440)NDd553 (400-1,498)784 (557-1,298)
    PGF (pg/ml)0.78 (0.31-2.94)1.22 (0.16-2.07)1.31 (0.22-2.33)2.95 (0.76-4.48)
    LTB4 (pg/ml)500 (77-711)†‡ND80 (47-500)79 (47-475)
    Lf (ng/ml)251 (173-360)‡177 (146-246)‡223 (200-325)‡115 (102-141)
    SOD (sp act [U/mg of protein)0.03 (0.024-0.034)0.04 (0.02-0.07)0.027 (0.023-0.031)0.03 (0.028-0.035)
    MPO (sp act [U/mg of protein])0.036 (0.028-0.045)0.026 (0.019-0.035)0.023 (0.017-0.032)0.02 (0.014-0.023)
    NO˙a metabolites (nmol/ml)248 (180-496)*†‡52 (12-164)‡56 (19-69)2.5 (1.0-32.0)
    CRP (mg/dl)0.92 (0.7-1.12)0.73 (0.57-0.88)UDUD
  • a Nitric oxide (NO) was measured as NO2 and NO3.

  • b Statistical significance (P ≤ 0.05) between patients at the acute stage and at convalescence at day 7 (*) or day 30 (†) after onset of disease in patients and between patients and healthy controls (‡) is indicated. Results are expressed as medians with ranges (25th to 75th percentiles) given in parentheses

  • c UD, below the detection limit.

  • d ND, not done for day 7 samples.