TABLE 2.

Effects of Ebola virus infection and LPS stimulation on cytokine and chemokine protein production in nonhuman primate alveolar macrophages

TimeTreatmentMean ± SEM concn (pg/ml) ofa:
IL-1βIL-6IL-8MIP-1αTNF-α
T0Mock infected001.71 ± 1.7101.11 ± 1.11
Infected08.19 ± 8.1924.20 ± 24.2000
T6LPS94.06 ± 29.38b55.51 ± 23.51b8,598.61 ± 1,025.66b1,940.59 ± 476.56b3,070.28 ± 870.74b
Mock infected00440.01 ± 155.2030.28 ± 26.880
Infected01.73 ± 1.42842.92 ± 306.37112.66 ± 57.691.44 ± 1.44
T12LPS216.69 ± 139.31b665.59 ± 314.41b26,098.57 ± 3,218.03b18,600.80 ± 5,287.57b5,625.12 ± 1,633.96b
Mock infected00.04 ± 0.04912.31 ± 394.92209.04 ± 122.6729.01 ± 24.95
Infected001,079.49 ± 368.21141.92 ± 113.451.44 ± 1.44
T24LPS212.95 ± 117.15b1,240.08 ± 666.67b37,840.58 ± 2,704.53b36,735.02 ± 4,850.02b5,966.06 ± 1,532.75b
Mock infected023.73 ± 23.73676.83 ± 287.05158.45 ± 127.000.00
Infected16.02 ± 7.60b7.24 ± 7.242,762.62 ± 1,076.25218.65 ± 143.03102.51 ± 56.35b
  • a Data are for alveolar macrophages from four different cynomolgus monkeys in four separate experiments.

  • b Value was significantly different (P < 0.05) from value for mock-infected cells at the same time point.